Car is loud when I accelerate, small single click noise when accelerating/braking. Safe to drive?

It's a 2003 Honda Accord V6 with 215k miles. The past two days it's been loud when accelerating but it can still accelerate fine (but I haven't driven over 45 mph with it like this). Also I noticed a small single click noise whenever I accelerate or when I brake. Not due for an oil change for another 500+ miles. I planned on driving it 275 miles on the highway at 70-80 mph tomorrow and another 275 back on Sunday.

Nothing to worry about or is it best to not drive that much on it?

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